Regelle works by lining the inside of the vagina, providing moisturisation, lubrication and comfort1
The polycarbophil-carbopol based vaginal gel has a high level of bio-adhesiveness capable of ensuring a prolonged moisturising action on the epithelium of the vaginal mucous membrane2
. This gel is capable of adhering to the vaginal mucous membranes thanks to the presence of two characteristic polyacid polymers having a high molecular weight and a molecular structure very similar to that of the vaginal mucous: Polycarbophil and carbopol2
. Polycarbophil is hydrophilic and provides direct cellular ‘moisturising’ action resulting from an increased flow of water molecules from outside to the inside of the cells on the surface of vaginal mucous membrane. This action creates a moist film over the vaginal wall hydrating the underlying mucosa3
. This movement of water into the cells of the vaginal epithelium is promoted by the particular unique structure of the polymers in this gel2
. Being bio-adhesive, Regelle has been shown in laboratory and clinical studies to adhere to tissue for 24-72h, resulting in diffusion of water from the gel to the underlying vaginal mucosa3
Furthermore, polycarbophil and carbopol are substances with a buffering action and their use in women experiencing menopause either naturally or as a result of surgery has led to a correction of the vaginal pH values comparable to those obtained with hormone replacement therapy4
The pH of the polycarbophil gel is 3.0 and it buffers to a normal vaginal pH of 3.5 to 5.03
is so safe patients can use it confidently for years, even decades, and with regular use some women may find that fewer applications are needed, because the dryness reduces.
coats vaginal tissues to provide instant relief to dry cells.
delivers continuous moisture, which the cells absorb, causing them to regain their natural structure and elasticity.
Dead skin cells are naturally shed leaving the vagina both moisturised and rejuvenated.
- Kora Healthcare Regelle Product Data Sheet
- Garg et al (2001) Properties of new acid buffering bioadhesive vaginal formulation. Contraception 64. 67-75.
- Gelfand, M et al (1994) Treating Vaginal Dryness in Brest Cancer Patients: Results of Applying a Polycarbophil Moisturizing Gel. Journal of Women’s Health; volume 3, Number 6, p427-433#
- Bachmann, G.A et al (1992) Long Term Nonhormonal Treatment of Vaginal Dryness. Clinical Practice in Sexuality; Volume 8, Number 8/9, p 3-8